China (Mainland)
Reliable quality of n hot selling 32222-06-3 supply Calcitriol CAS NO.32222-06-3
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- Min.Order: 1 Gram
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- Available Specifications:
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- Reliable quality of 32222-06-3
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Quick Details
- ProName: Reliable quality of n hot selling 3222...
- CasNo: 32222-06-3
- Molecular Formula: C27H44O3
- Appearance: WHITE POWDER
- Application: API
- DeliveryTime: PROMPT
- PackAge: PROPER
- Port: ANY CHINA PORT
- ProductionCapacity: 1 Gram/Day
- Purity: 99%
- Storage: NORMAL TEMPERATURE
- Transportation: AIR, COURIER
- LimitNum: 1 Gram
- Related Substances: 0.01%
- Residue on Ignition: 0.01%
- Heavy Metal: 0.01%
- Valid Period: YEARS
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Zhejiang Sa-chen pharmaceutical technology company is a subsidiary of Heze Pharma. Which is committed to import and export of Hormone and steroid API and intermediates, Pharmaceutical Raw material and intermediates and APIs registration since the foundation.
Company possessed a professional marketing team, with the support of several GMP factories partners’ assistant, company build a strategy partnership with the GMP factories which located in Zhejiang, Hunan, Jiangsu provinces, which make us own the reputation all over the world.
Our head company Heze Pharma is a MAH (Marketing Authorization Holder) enterprise which is seeking to the cooperation with foreign GMP factory for the API registration in China, to achieving Mutual Benefit and Common Development. With decade of professional experience in API and formulation registration, Heze Pharma is familiar with related regulatory.
Heze possessed a professional registration team, which can assistant customers for the API registration in China with the DMF audit, translation and application process. We can work as a sole agent for the API registration and sales, to assist customers for the API registration in China, or we can work as agent of registration, assist customers for the API registration.
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| Calcitriol Basic information |
| Product Name: | Calcitriol |
| Synonyms: | Calcitriol Impurity;(5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol;1,25-dhcc;1,25-dihydroxycholecalciferol;1,25-dihydroxyvitamind;1a,25-dihydroxy-cholecalcifero;1-alpha,25-dihydroxy-cholecalcifero;Vitamin D3, 1a,25-Dihydroxy- |
| CAS: | 32222-06-3 |
| MF: | C27H44O3 |
| MW: | 416.64 |
| EINECS: | 250-963-8 |
| Product Categories: | -;Miscellaneous Biochemicals;Vitamin D3 analogs;API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Isolabel;reagent;standard substance |
| Mol File: | 32222-06-3.mol |
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| Calcitriol Chemical Properties |
| Melting point | 119-1210C |
| alpha | D25 +48° (methanol) |
| Boiling point | 474.91°C (rough estimate) |
| density | 1.0362 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| Fp | 14 °C |
| storage temp. | 2-8°C |
| solubility | Do you have solubility information on this product that you would like to share |
| form | Solid |
| λmax | 265nm(lit.) |
| Merck | 14,1644 |
| BRN | 7559394 |
| Stability: | Air and Light Sensitive |
| InChIKey | GMRQFYUYWCNGIN-UNVJKIGWSA-N |
| CAS DataBase Reference |
32222-06-3(CAS DataBase Reference) |
Details
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Description Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.